CKDdb-logoCKDdb - Molecule ID A6009

geneCBR1, CBR, CRN
nameCarbonyl reductase [NADPH] 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CBR1_HUMANP16152ENSG00000159228873Hs.606200114830

Functions and classifications

GOC:cytosol, F:15-hydroxyprostaglandin dehydrogenase (NADP+) activity, F:carbonyl reductase (NADPH) activity, F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, F:prostaglandin-E2 9-reductase activity, P:cyclooxygenase pathway, P:drug metabolic process, P:vitamin K metabolic process, F:oxidoreductase activity, P:oxidation-reduction process, C:cytoplasm, F:nucleotide binding, F:oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
UniProt3D-structure, Acetylation, Complete proteome, Cytoplasm, Direct protein sequencing, NADP, Oxidoreductase, Polymorphism, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)5.180.05RNA microarray17579666
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.330cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.460.01cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.420.0106RNA microarray19698090
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.290.000000317RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium