CKDdb-logoCKDdb - Molecule ID A598F

nameCalpain 3
speciesHomo sapiens

Molecule reference

CAN3_HUMANP20807ENSP00000336840825Hs.143261114240, 253600

Functions and classifications

GOC:cytosol, C:nucleus, C:protein complex, C:T-tubule, C:Z disc, F:calcium ion binding, F:calcium-dependent cysteine-type endopeptidase activity, F:ligase regulator activity, F:protein complex scaffold, F:signal transducer activity, F:sodium ion binding, F:structural constituent of muscle, P:apoptotic process, P:autolysis, P:cellular response to calcium ion, P:cellular response to salt stress, P:G1 to G0 transition involved in cell differentiation, P:muscle cell cellular homeostasis, P:muscle organ development, P:negative regulation of apoptotic process, P:negative regulation of protein sumoylation, P:negative regulation of transcription, DNA-templated, P:positive regulation of NF-kappaB transcription factor activity, P:positive regulation of proteolysis, P:positive regulation of release of sequestered calcium ion into cytosol, P:positive regulation of satellite cell activation involved in skeletal muscle regeneration, P:positive regulation of transcription, DNA-templated, P:protein complex assembly, P:protein localization to membrane, P:regulation of I-kappaB kinase/NF-kappaB signaling, P:regulation of myoblast differentiation, P:response to muscle activity, P:sarcomere organization, P:self proteolysis, C:intracellular, P:proteolysis, P:muscle cell homeostasis, P:negative regulation of transcription, DNA-dependent, P:positive regulation of transcription, DNA-dependent, P:regulation of I-kappaB kinase/NF-kappaB cascade, P:response to drug, C:plasma membrane
UniProt3D-structure, Alternative splicing, Calcium, Complete proteome, Cytoplasm, Disease mutation, Hydrolase, Limb-girdle muscular dystrophy, Metal-binding, Polymorphism, Protease, Reference proteome, Repeat, Thiol protease
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp15042541Homo sapiens4kidneyglomeruliDiabetes (diabetic nephropathy)3.9< 0.01RNA microarray15042541
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.560.000486783RNA microarray20019191
Exp24172336Mus musculus6kidneycortexAKI (AKI)10000.001736533LC-MS/MS24172336

Compile date 08-10-2018© iMODE-CKD consortium