CKDdb-logoCKDdb - Molecule ID A5978

geneCASP4, ICH2, mih1/Tx
nameCaspase-4 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CASP4_HUMANP49662ENSG00000196954837Hs.138378602664

Functions and classifications

GOC:endoplasmic reticulum membrane, C:mitochondrion, F:cysteine-type endopeptidase activity, P:apoptotic process, P:proteolysis, P:regulation of apoptotic process, C:intracellular, P:induction of apoptosis
UniProtAlternative splicing, Apoptosis, Complete proteome, Endoplasmic reticulum, Hydrolase, Membrane, Mitochondrion, Phosphoprotein, Polymorphism, Protease, Reference proteome, Thiol protease, Zymogen
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)15.1< 0.05RNA microarray18187931
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.243.62E-09RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)3.513.23E-06RNA microarray20019191
Exp20706631Mus musculus6kidneyglomerular capillary endothelial cellDiabetes (diabetic nephropathy)0.44< 0.05RNA microarray20706631
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)6.4< 0.05RNA microarray21752957
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.71< 0.05RNA-seq23757392
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.364.95E-06RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.377.55E-06RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium