CKDdb-logoCKDdb - Molecule ID A5966

geneCA4
nameCarbonic anhydrase IV precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CAH4_HUMANP22748ENSG00000167434762Hs.89485114760, 600852

Functions and classifications

GOC:anchored component of external side of plasma membrane, C:apical plasma membrane, C:brush border membrane, C:endoplasmic reticulum-Golgi intermediate compartment, C:Golgi apparatus, C:perinuclear region of cytoplasm, C:rough endoplasmic reticulum, C:sarcolemma, C:sarcoplasmic reticulum, C:secretory granule membrane, C:trans-Golgi network, C:transport vesicle membrane, F:carbonate dehydratase activity, F:zinc ion binding, P:bicarbonate transport, P:one-carbon metabolic process, P:organ development, P:response to drug, P:response to steroid hormone, P:small molecule metabolic process, C:anchored component of membrane, C:plasma membrane, P:metabolic process, C:anchored component of plasma membrane, C:anchored to external side of plasma membrane, F:metal ion binding, P:response to steroid hormone stimulus, C:anchored to membrane, C:anchored to plasma membrane
UniProt3D-structure, Cell membrane, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Lyase, Membrane, Metal-binding, Polymorphism, Reference proteome, Retinitis pigmentosa, Signal, Zinc
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.49< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.54< 0.05cDNA microarray17003339
Exp19070598aMus musculus36kidneywholeDiabetes (diabetic nephropathy)0.56< 0.05cDNA microarray19070598
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.410cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.340.01cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.110.000000558RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.110.0000132RNA microarray19698090
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)0.450.012MALDI-TOF/TOF21544065
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)3.20.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium