CKDdb-logoCKDdb - Molecule ID A5964

geneCa2, Car2
nameCarbonic anhydrase 2
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CAH2_MOUSEP00920ENSMUSG0000002756212349Mm.1186259730, 611492

Functions and classifications

GOC:apical part of cell, C:axon, C:basolateral plasma membrane, C:cytoplasm, C:cytosol, C:extracellular space, C:microvillus, C:myelin sheath, C:plasma membrane, F:carbonate dehydratase activity, F:zinc ion binding, P:angiotensin-activated signaling pathway, P:carbon dioxide transport, P:kidney development, P:morphogenesis of an epithelium, P:odontogenesis of dentin-containing tooth, P:one-carbon metabolic process, P:positive regulation of bone resorption, P:positive regulation of cellular pH reduction, P:positive regulation of dipeptide transmembrane transport, P:positive regulation of osteoclast differentiation, P:positive regulation of synaptic transmission, GABAergic, P:regulation of anion transport, P:regulation of chloride transport, P:regulation of intracellular pH, P:response to estrogen, P:response to pH, P:response to zinc ion, P:secretion, F:metal ion binding, P:response to estrogen stimulus, P:response to stress
UniProtAcetylation, Cell membrane, Complete proteome, Cytoplasm, Direct protein sequencing, Lyase, Membrane, Metal-binding, Reference proteome, Zinc
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.45< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.92< 0.05cDNA microarray17003339
Exp17609286Mus musculus10kidneyglomeruliDiabetes (diabetic nephropathy in Type 1 diabetes)up< 0.05MALDI-TOF-MS17609286
Exp20007950aRattus norvegicus8corporawholeDiabetes (Diabetes Mellitus-associated Erectile Dysfunction)1.670.012MALDI-TOF, LC-MS/MS20007950
Exp20007950bRattus norvegicus8corporawholeDiabetes (Diabetes Mellitus-associated Erectile Dysfunction)1.110.012MALDI-TOF, LC-MS/MS20007950
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp20940332Mus musculus kidneycollecting duct cellsVasopressine_induced (Vasopressine in vitro model)1.62< 0.05LC-MS/MS20940332
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)7.240.023MALDI-TOF/TOF21544065
Exp21595033bHomo sapiens14urineexosomesGlomerulonephritis (basement membrane nephropathy)0.280.00407LC-MS/MS21595033
Exp22172726Homo sapiens20kidneyglomeruliDiabetes (type 2 diabetic nephropathy)0.750.0001QSTAR Elite LC-MS/MS22172726
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)0.6 nLC-ESI-UHR-QToF-MS/MS23344851
Exp24211404Homo sapiens16urineexosomeDiabetes (diabetic nephropathy)0.160.00001LC-MS/MS24211404

Compile date 08-10-2018© iMODE-CKD consortium