CKDdb-logoCKDdb - Molecule ID A595F

geneCALCRL, CGRPR
nameCalcitonin gene-related peptide type 1 receptor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CALRL_HUMANQ16602ENSG0000006498910203Hs.470882114190

Functions and classifications

GOC:endoplasmic reticulum, C:endosome, C:integral component of plasma membrane, C:lysosome, F:adrenomedullin receptor activity, F:calcitonin gene-related polypeptide receptor activity, F:calcitonin receptor activity, F:protein transporter activity, P:adenylate cyclase-activating G-protein coupled receptor signaling pathway, P:angiogenesis, P:calcium ion transport, P:cAMP biosynthetic process, P:cellular response to sucrose stimulus, P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, P:heart development, P:negative regulation of inflammatory response, P:positive regulation of cAMP biosynthetic process, P:positive regulation of smooth muscle cell proliferation, P:receptor internalization, P:regulation of muscle contraction, C:membrane, P:regulation of muscle contraction, C:integral component of membrane, C:plasma membrane, C:integral to plasma membrane, C:integral to membrane
UniProt3D-structure, Cell membrane, Complete proteome, Direct protein sequencing, Disulfide bond, G-protein coupled receptor, Glycoprotein, Membrane, Polymorphism, Receptor, Reference proteome, Signal, Transducer, Transmembrane, Transmembrane helix
PADBreceptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.320.00382RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)2.953.23E-06RNA microarray20019191
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)4.020.004788RNA microarray23935909
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.311.17E-05RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.280.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium