CKDdb-logoCKDdb - Molecule ID A5940

geneBRCC3, BRCC36, C6.1A
nameLys-63-specific deubiquitinase BRCC36
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BRCC3_HUMANP46736ENSG0000018551579184Hs.558537300617

Functions and classifications

GOC:BRCA1-A complex, C:BRISC complex, C:nuclear ubiquitin ligase complex, F:enzyme regulator activity, F:metal ion binding, F:metallopeptidase activity, F:polyubiquitin binding, F:ubiquitin thiolesterase activity, F:ubiquitin-specific protease activity, P:double-strand break repair, P:G2 DNA damage checkpoint, P:histone H2A K63-linked deubiquitination, P:positive regulation of DNA repair, P:proteolysis, P:response to X-ray, P:G2/M transition DNA damage checkpoint
UniProtAcetylation, Alternative splicing, Chromatin regulator, Chromosomal rearrangement, Complete proteome, Direct protein sequencing, DNA damage, DNA repair, Hydrolase, Metal-binding, Metalloprotease, Nucleus, Polymorphism, Protease, Proto-oncogene, Reference proteome, Ubl conjugation pathway, Zinc
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.455.90E-06RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium