CKDdb-logoCKDdb - Molecule ID A5936

geneBBOX1, BBH, BBOX
nameGamma-butyrobetaine dioxygenase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BODG_HUMANO75936ENSG000001291518424Hs.591996603312

Functions and classifications

GOC:actin cytoskeleton, C:cytosol, C:intracellular membrane-bounded organelle, C:mitochondrion, F:gamma-butyrobetaine dioxygenase activity, F:iron ion binding, F:zinc ion binding, P:carnitine biosynthetic process, F:iron ion binding, F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, P:carnitine biosynthetic process, C:actin cytoskeleton, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
UniProt3D-structure, Carnitine biosynthesis, Complete proteome, Cytoplasm, Dioxygenase, Iron, Metal-binding, Oxidoreductase, Reference proteome, Zinc
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)40.05RNA microarray17579666
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.340.0157RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.241.50E-05RNA microarray20019191
Exp23502960aMus musculus8kidneyglomeruliGlomerulonephritis (FSGS)41.84 qPCR23502960
Exp23502960bMus musculus kidneyglomeruliGlomerulonephritis (FSGS)0.98 qPCR23502960

Compile date 08-10-2018© iMODE-CKD consortium