CKDdb-logoCKDdb - Molecule ID A5935

geneBMPR2, PPH1
nameBone morphogenetic protein receptor type II (serine/threonine kinase) precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BMPR2_HUMANQ13873ENSP00000363708659Hs.471119178600, 265450, 600799

Functions and classifications

GOC:apical plasma membrane, C:basal plasma membrane, C:caveola, C:cell surface, C:cytoplasm, C:dendrite, C:integral component of plasma membrane, C:neuronal cell body, F:activin receptor activity, type II, F:ATP binding, F:metal ion binding, F:transforming growth factor beta-activated receptor activity, P:anterior/posterior pattern specification, P:artery development, P:blood vessel remodeling, P:BMP signaling pathway, P:brain development, P:cellular response to starvation, P:lung alveolus development, P:lymphangiogenesis, P:lymphatic endothelial cell differentiation, P:mesoderm formation, P:negative regulation of cell growth, P:negative regulation of DNA biosynthetic process, P:negative regulation of systemic arterial blood pressure, P:negative regulation of vasoconstriction, P:positive regulation of BMP signaling pathway, P:positive regulation of bone mineralization, P:positive regulation of endothelial cell migration, P:positive regulation of endothelial cell proliferation, P:positive regulation of osteoblast differentiation, P:positive regulation of pathway-restricted SMAD protein phosphorylation, P:regulation of lung blood pressure, P:retina vasculature development in camera-type eye, P:transcription from RNA polymerase II promoter, P:vascular endothelial growth factor receptor signaling pathway, P:venous blood vessel development, C:membrane, P:transmembrane receptor protein serine/threonine kinase signaling pathway, P:positive regulation of protein phosphorylation, C:integral to plasma membrane, P:positive regulation of epithelial cell migration
UniProt3D-structure, ATP-binding, Complete proteome, Disease mutation, Disulfide bond, Glycoprotein, Kinase, Magnesium, Manganese, Membrane, Metal-binding, Nucleotide-binding, Phosphoprotein, Polymorphism, Receptor, Reference proteome, Serine/threonine-protein kinase, Signal, Transferase, Transmembrane, Transmembrane helix
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)2.993.23E-06RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)3.463.23E-06RNA microarray20019191
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy)0.610.01hybrid quadrupole-TOF, LC-MS/MS22536212

Compile date 08-10-2018© iMODE-CKD consortium