CKDdb-logoCKDdb - Molecule ID A5917

geneBACE2, AEPLC, ALP56
nameBeta secretase 2 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BACE2_HUMANQ9Y5Z0ENSG0000018224025825Hs.43047605668

Functions and classifications

GOC:cell surface, C:endoplasmic reticulum, C:endosome, C:Golgi apparatus, C:integral component of membrane, F:aspartic-type endopeptidase activity, P:membrane protein ectodomain proteolysis, P:negative regulation of amyloid precursor protein biosynthetic process, P:peptide hormone processing, P:proteolysis, C:integral to membrane
UniProt3D-structure, Alternative splicing, Aspartyl protease, Autocatalytic cleavage, Complete proteome, Direct protein sequencing, Disulfide bond, Endoplasmic reticulum, Endosome, Glycoprotein, Golgi apparatus, Hydrolase, Membrane, Protease, Reference proteome, Signal, Transmembrane, Transmembrane helix, Zymogen
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.170.000000327RNA microarray19698090
Exp23760282aMus musculus kidneywholeureteral_obstruction (renal tubulointerstitial injury)0.450.046RNA microarray23760282
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)5.610.0166331RNA microarray23935909

Compile date 08-10-2018© iMODE-CKD consortium