CKDdb-logoCKDdb - Molecule ID A5912

geneB4GALT1, GGTB2
nameBeta-1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
B4GT1_HUMANP15291ENSG000000860622683Hs.272011137060, 607091

Functions and classifications

GOC:basolateral plasma membrane, C:brush border membrane, C:desmosome, C:external side of plasma membrane, C:extracellular region, C:glycocalyx, C:Golgi cisterna membrane, C:Golgi membrane, C:Golgi trans cisterna, C:integral component of membrane, F:alpha-tubulin binding, F:beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, F:lactose synthase activity, F:manganese ion binding, F:N-acetyllactosamine synthase activity, F:protein homodimerization activity, P:acute inflammatory response, P:angiogenesis involved in wound healing, P:binding of sperm to zona pellucida, P:branching morphogenesis of an epithelial tube, P:cell adhesion, P:development of secondary sexual characteristics, P:epithelial cell development, P:extracellular matrix organization, P:galactose metabolic process, P:keratan sulfate biosynthetic process, P:lactose biosynthetic process, P:leukocyte migration, P:mammary gland development, P:multicellular organism reproduction, P:negative regulation of cell proliferation, P:Notch signaling pathway, P:oligosaccharide biosynthetic process, P:penetration of zona pellucida, P:positive regulation of apoptotic process involved in mammary gland involution, P:positive regulation of epithelial cell proliferation involved in wound healing, P:post-translational protein modification, P:protein N-linked glycosylation via asparagine, P:regulation of acrosome reaction, P:regulation of cellular component movement, F:transferase activity, transferring glycosyl groups, P:carbohydrate metabolic process, C:cell surface, C:Golgi apparatus, C:plasma membrane, F:galactosyltransferase activity, P:glycoprotein biosynthetic process, P:regulation of cellular component movement, C:Golgi apparatus, F:transferase activity, transferring glycosyl groups, C:integral to membrane, F:metal ion binding, P:branching morphogenesis of a tube, C:cell surface, P:protein glycosylation
UniProt3D-structure, Alternative initiation, Cell membrane, Complete proteome, Congenital disorder of glycosylation, Direct protein sequencing, Disulfide bond, Glycoprotein, Glycosyltransferase, Golgi apparatus, Manganese, Membrane, Metal-binding, Polymorphism, Reference proteome, Secreted, Signal-anchor, Transferase, Transmembrane, Transmembrane helix
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.030.01cDNA microarray19099603
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.380.0225181RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.480.000385RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.480.0339RNA microarray19698090
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.36< 0.05RNA microarray21752957
Exp24189015aHomo sapiens5bloodmononuclear cellshealthy (healthy)2.38 +/- 0.44< 0.001RNA microarray24189015
Exp24189015aHomo sapiens5bloodmononuclear cellshealthy (healthy)5.10 +/- 0.4< 0.001RNA microarray24189015
Exp24189015bHomo sapiens9bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)1.58 +/- 0.83< 0.001RNA microarray24189015
Exp24189015bHomo sapiens9bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)5.00 +/- 0.4< 0.001RNA microarray24189015
Exp24189015cHomo sapiens10bloodmononuclear cellsDialysis (Peritoneal dialysis)1.82 +/- 0.88< 0.001RNA microarray24189015
Exp24189015cHomo sapiens10bloodmononuclear cellsDialysis (Peritoneal dialysis)4.09 +/- 0.69< 0.001RNA microarray24189015
Exp24189015dHomo sapiens17bloodmononuclear cellsDialysis (hemodialysis)2.09 +/- 0.59< 0.001RNA microarray24189015
Exp24189015dHomo sapiens17bloodmononuclear cellsDialysis (hemodialysis)4.38 +/- 0.37< 0.001RNA microarray24189015

Compile date 08-10-2018© iMODE-CKD consortium