CKDdb-logoCKDdb - Molecule ID A5892

nameActivin receptor type-2A
speciesHomo sapiens

Molecule reference


Functions and classifications

GOC:cell surface, C:cytoplasm, C:inhibin-betaglycan-ActRII complex, C:integral component of plasma membrane, F:ATP binding, F:coreceptor activity, F:metal ion binding, F:receptor signaling protein serine/threonine kinase activity, F:transforming growth factor beta-activated receptor activity, F:transmembrane receptor protein serine/threonine kinase activity, P:activin receptor signaling pathway, P:anterior/posterior pattern specification, P:BMP signaling pathway, P:determination of left/right symmetry, P:embryonic skeletal system development, P:gastrulation with mouth forming second, P:intracellular signal transduction, P:mesoderm development, P:penile erection, P:positive regulation of activin receptor signaling pathway, P:positive regulation of bone mineralization, P:positive regulation of erythrocyte differentiation, P:positive regulation of osteoblast differentiation, P:positive regulation of pathway-restricted SMAD protein phosphorylation, P:regulation of BMP signaling pathway, P:regulation of nitric-oxide synthase activity, P:Sertoli cell proliferation, P:signal transduction by phosphorylation, P:sperm ejaculation, P:spermatogenesis, C:membrane, "C:cell surface, C:integral to plasma membrane, F:activin receptor activity, type II, P:positive regulation of follicle-stimulating hormone secretion, P:response to organic substance, P:spermatogenesis"
UniProt3D-structure, ATP-binding, Complete proteome, Disulfide bond, Glycoprotein, Kinase, Magnesium, Manganese, Membrane, Metal-binding, Nucleotide-binding, Polymorphism, Receptor, Reference proteome, Serine/threonine-protein kinase, Signal, Transferase, Transmembrane, Transmembrane helix
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.422.37E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium