CKDdb-logoCKDdb - Molecule ID A5891

geneAurkb, Aik2, Aim1
nameAurora kinase B
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AURKB_MOUSEO70126ENSMUSG0000002089720877Mm.3488604970

Functions and classifications

GOC:chromocenter, C:chromosome passenger complex, C:condensed nuclear chromosome, centromeric region, C:cytoplasm, C:kinetochore, C:midbody, C:mitotic spindle pole, C:nucleus, F:ATP binding, F:histone serine kinase activity, F:metal ion binding, F:protein binding, F:protein serine/threonine kinase activity, P:aging, P:cell proliferation, P:cellular response to UV, P:cleavage furrow formation, P:histone H3-S28 phosphorylation, P:negative regulation of B cell apoptotic process, P:negative regulation of protein binding, P:negative regulation of transcription from RNA polymerase II promoter, P:positive regulation of cytokinesis, P:protein localization to kinetochore, P:spindle checkpoint, P:spindle midzone assembly involved in mitosis, P:spindle stabilization, C:spindle, P:positive regulation of cell cycle cytokinesis
UniProtATP-binding, Cell cycle, Cell division, Centromere, Chromosome, Complete proteome, Cytoplasm, Cytoskeleton, Kinase, Magnesium, Metal-binding, Mitosis, Nucleotide-binding, Nucleus, Phosphoprotein, Reference proteome, Serine/threonine-protein kinase, Transferase, Ubl conjugation
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.40cDNA microarray21411733
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)12.66< 0.05RNA-seq23757392
Exp23757392cRattus norvegicus18kidneywholeDiabetes (diabetic nephropathy)3.95< 0.05RNA-seq23757392
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.262.98E-03RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium