CKDdb-logoCKDdb - Molecule ID A5887

geneADAMTS7
nameADAM metallopeptidase with Thrombospondin type 1 motif
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ATS7_HUMANQ9UKP4ENSG0000013637811173Hs.16441605009

Functions and classifications

GOC:cell surface, C:proteinaceous extracellular matrix, F:metalloendopeptidase activity, F:zinc ion binding, P:cellular response to BMP stimulus, P:cellular response to interleukin-1, P:cellular response to tumor necrosis factor, P:negative regulation of chondrocyte differentiation, P:proteolysis involved in cellular protein catabolic process, C:extracellular region, P:integrin-mediated signaling pathway, P:proteolysis, F:peptidase activity, P:metabolic process, F:metal ion binding, F:metallopeptidase activity
UniProtCleavage on pair of basic residues, Complete proteome, Direct protein sequencing, Disulfide bond, Extracellular matrix, Glycoprotein, Hydrolase, Metal-binding, Metalloprotease, Polymorphism, Protease, Proteoglycan, Reference proteome, Repeat, Secreted, Signal, Zinc, Zymogen, Integrin
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)3.180.0017987RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.280.000106RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.410.0137RNA microarray19698090
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.58< 0.05RNA-seq23757392

Compile date 08-10-2018© iMODE-CKD consortium