CKDdb-logoCKDdb - Molecule ID A5886

geneADAMTS2, PCINP, PCPNI
nameADAMTS-2 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ATS2_HUMANO95450ENSG000000871169509Hs.23871225410, 604539

Functions and classifications

GOC:extracellular region, C:proteinaceous extracellular matrix, F:metalloendopeptidase activity, F:zinc ion binding, P:collagen catabolic process, P:collagen fibril organization, P:extracellular matrix organization, P:lung development, P:protein processing, P:proteolysis, P:skin development, P:spermatogenesis, F:metal ion binding
UniProtAlternative splicing, Collagen degradation, Complete proteome, Disulfide bond, Ehlers-Danlos syndrome, Extracellular matrix, Glycoprotein, Hydrolase, Metal-binding, Metalloprotease, Polymorphism, Protease, Reference proteome, Repeat, Secreted, Signal, Zinc, Zymogen
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19398767Homo sapiens20kidneybiopsy sectionFibrosis (Interstitial fibrosis and tubular atrophy)2.250.000860785RNA microarray19398767
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.190.00000473RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.230.000179RNA microarray19698090
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.48< 0.05RNA-seq23757392
Exp23757392cRattus norvegicus18kidneywholeDiabetes (diabetic nephropathy)2.27< 0.05RNA-seq23757392
Exp24172336Mus musculus6kidneycortexAKI (AKI)10000.018792802LC-MS/MS24172336

Compile date 08-10-2018© iMODE-CKD consortium