CKDdb-logoCKDdb - Molecule ID A5884

geneADAMTS18, ADAMTS21
nameA disintegrin and metalloproteinase with thrombospondin motifs 18
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ATS18_HUMANQ8TE60ENSG00000140873170692Hs.188746607512, 608454

Functions and classifications

GOC:proteinaceous extracellular matrix, F:metalloendopeptidase activity, F:zinc ion binding, P:proteolysis, P:integrin-mediated signaling pathway, P:metabolic process, F:metallopeptidase activity, F:metal ion binding
UniProtAlternative splicing, Cleavage on pair of basic residues, Complete proteome, Disulfide bond, Extracellular matrix, Glycoprotein, Hydrolase, Metal-binding, Metalloprotease, Polymorphism, Protease, Reference proteome, Repeat, Secreted, Signal, Zinc, Zymogen, Integrin, Disease mutation
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.180.014197RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium