CKDdb-logoCKDdb - Molecule ID A5881

geneADAMTS13, UNQ6102/PRO20085, vWF-CP
nameA disintegrin-like and metalloprotease (Reprolysin type) with thrombospondin type 1 motif
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ATS13_HUMANQ76LX8ENSG0000016032311093Hs.131433274150, 604134

Functions and classifications

GOC:cell surface, C:extracellular space, C:proteinaceous extracellular matrix, F:calcium ion binding, F:integrin binding, F:metalloendopeptidase activity, F:metallopeptidase activity, F:zinc ion binding, P:cell-matrix adhesion, P:glycoprotein metabolic process, P:integrin-mediated signaling pathway, P:peptide catabolic process, P:platelet activation, P:protein processing, P:proteolysis, P:response to interferon-gamma, P:response to interleukin-4, P:response to tumor necrosis factor, F:hydrolase activity, P:metabolic process, F:endopeptidase activity, F:peptidase activity
UniProt3D-structure, Alternative splicing, Blood coagulation, Calcium, Cleavage on pair of basic residues, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Glycoprotein, Hemostasis, Hydrolase, Metal-binding, Metalloprotease, Polymorphism, Protease, Reference proteome, Repeat, Secreted, Signal, Zinc, Zymogen
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.130.000000584RNA microarray19698090

Compile date 08-10-2018© iMODE-CKD consortium