CKDdb-logoCKDdb - Molecule ID A5880

geneADAMTS12, UNQ1918/PRO4389, UNQ1918
nameADAM metallopeptidase with thrombospondin type 1 motif
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ATS12_HUMANP58397ENSG0000015138881792Hs.12680606184

Functions and classifications

GOC:proteinaceous extracellular matrix, F:metalloendopeptidase activity, F:zinc ion binding, P:proteolysis, F:metal ion binding
UniProtAlternative splicing, Cleavage on pair of basic residues, Complete proteome, Disulfide bond, Extracellular matrix, Glycoprotein, Hydrolase, Metal-binding, Metalloprotease, Polymorphism, Protease, Reference proteome, Repeat, Secreted, Signal, Zinc, Zymogen, Phosphoprotein
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.340.00163RNA microarray19698090
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.58< 0.05RNA-seq23757392
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.39.45E-04RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.170.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium