CKDdb-logoCKDdb - Molecule ID A5878

geneADAMTS1, METH1
nameADAMTS-1 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ATS1_HUMANQ9UHI8ENSG000001547349510Hs.643357605174

Functions and classifications

GOC:basement membrane, C:cytoplasmic vesicle, F:heparin binding, F:metalloendopeptidase activity, F:metallopeptidase activity, F:zinc ion binding, P:heart trabecula formation, P:integrin-mediated signaling pathway, P:kidney development, P:negative regulation of cell proliferation, P:ovulation from ovarian follicle, P:proteolysis, C:proteinaceous extracellular matrix, F:metal ion binding
UniProt3D-structure, Calcium, Cleavage on pair of basic residues, Complete proteome, Disulfide bond, Extracellular matrix, Glycoprotein, Heparin-binding, Hydrolase, Metal-binding, Metalloprotease, Polymorphism, Protease, Reference proteome, Repeat, Secreted, Signal, Zinc, Zymogen, Integrin
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp20813037cRattus norvegicus6kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)2.82.21E-07RNA microarray20813037
Exp22343120Homo sapiens39kidney AKI (AKI)40RNA microarray22343120
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)4.71< 0.05RNA-seq23757392
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)2.930.00000627RNA microarray24569379
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.280.014348RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium