CKDdb-logoCKDdb - Molecule ID A5877

geneATR, FRP1
nameSerine-protein kinase ATR
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ATR_HUMANQ13535ENSG00000175054545Hs.271791210600, 601215, 614564

Functions and classifications

GOC:chromosome, C:PML body, C:XY body, F:ATP binding, F:DNA binding, F:MutLalpha complex binding, F:MutSalpha complex binding, F:protein serine/threonine kinase activity, P:cellular response to gamma radiation, P:cellular response to UV, P:DNA damage checkpoint, P:DNA repair, P:DNA replication, P:multicellular organismal development, P:negative regulation of DNA replication, P:peptidyl-serine phosphorylation, P:positive regulation of DNA damage response, signal transduction by p53 class mediator, P:protein autophosphorylation, P:regulation of protein binding, P:replicative senescence, P:response to drug, F:ATP binding, F:kinase activity, F:phosphotransferase activity, alcohol group as acceptor, F:phosphotransferase activity, alcohol group as acceptor, P:metabolic process, C:nucleoplasm, P:cell cycle, P:replicative senescence, F:kinase activity, F:phosphotransferase activity, alcohol group as acceptor
UniProtAlternative splicing, ATP-binding, Chromosome, Complete proteome, Disease mutation, DNA damage, DNA repair, DNA-binding, Dwarfism, Kinase, Manganese, Mental retardation, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Serine/threonine-protein kinase, Transferase
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.340.000252RNA microarray19698090
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.330.0000775RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium