CKDdb-logoCKDdb - Molecule ID A5874

geneATP7B, PWD, WC1
nameCopper-transporting ATPase 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ATP7B_HUMANP35670ENSG00000123191540Hs.492280277900, 606882

Functions and classifications

GOC:Golgi membrane, C:integral component of plasma membrane, C:late endosome, C:mitochondrion, C:trans-Golgi network, F:ATP binding, F:copper ion binding, F:copper-exporting ATPase activity, P:cellular copper ion homeostasis, P:cellular zinc ion homeostasis, P:copper ion import, P:intracellular copper ion transport, P:lactation, P:response to copper ion, P:sequestering of calcium ion, C:integral component of membrane, F:cation-transporting ATPase activity, P:ATP catabolic process, P:copper ion transport, P:ion transmembrane transport, C:membrane, F:metal ion binding, F:nucleotide binding, P:copper ion export, P:metal ion transport, C:integral to plasma membrane, P:ATP biosynthetic process, C:integral to membrane, F:copper-transporting ATPase activity, C:membrane, F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, P:cation transport, F:hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
UniProt3D-structure, Alternative splicing, ATP-binding, Complete proteome, Copper, Copper transport, Cytoplasm, Disease mutation, Golgi apparatus, Hydrolase, Ion transport, Magnesium, Membrane, Metal-binding, Mitochondrion, Nucleotide-binding, Polymorphism, Reference proteome, Repeat, Transmembrane, Transmembrane helix, Transport
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.420.0349RNA microarray19698090

Compile date 08-10-2018© iMODE-CKD consortium