CKDdb-logoCKDdb - Molecule ID A5873

geneATP7A, MC1, MNK
nameCopper-transporting ATPase 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ATP7A_HUMANQ04656ENSG00000165240538Hs.496414300011, 300489, 304150, 309400

Functions and classifications

GOC:basolateral plasma membrane, C:brush border membrane, C:cytosol, C:endoplasmic reticulum, C:integral component of membrane, C:late endosome, C:neuron projection, C:neuronal cell body, C:perinuclear region of cytoplasm, C:secretory granule, C:trans-Golgi network, C:trans-Golgi network transport vesicle, F:ATP binding, F:copper-exporting ATPase activity, F:superoxide dismutase copper chaperone activity, P:blood vessel development, P:blood vessel remodeling, P:cartilage development, P:cellular copper ion homeostasis, P:cerebellar Purkinje cell differentiation, P:collagen fibril organization, P:copper ion import, P:dendrite morphogenesis, P:detoxification of copper ion, P:dopamine metabolic process, P:elastic fiber assembly, P:elastin biosynthetic process, P:epinephrine metabolic process, P:hair follicle morphogenesis, P:in utero embryonic development, P:lactation, P:locomotory behavior, P:lung alveolus development, P:mitochondrion organization, P:negative regulation of metalloenzyme activity, P:negative regulation of neuron apoptotic process, P:neuron projection morphogenesis, P:norepinephrine biosynthetic process, P:norepinephrine metabolic process, P:peptidyl-lysine modification, P:pigmentation, P:positive regulation of metalloenzyme activity, P:positive regulation of oxidoreductase activity, P:pyramidal neuron development, P:regulation of gene expression, P:regulation of oxidative phosphorylation, P:release of cytochrome c from mitochondria, P:removal of superoxide radicals, P:response to iron(III) ion, P:response to zinc ion, P:serotonin metabolic process, P:T-helper cell differentiation, P:tryptophan metabolic process, P:tyrosine metabolic process, F:copper ion binding, P:copper ion transport, F:cation-transporting ATPase activity, P:ATP catabolic process, P:ion transmembrane transport, C:integral to membrane, P:ATP biosynthetic process, P:skin development, C:membrane, F:copper-transporting ATPase activity, C:integral to membrane, F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, P:metal ion transport
UniProt3D-structure, Alternative splicing, ATP-binding, Cell membrane, Complete proteome, Copper, Copper transport, Cytoplasm, Disease mutation, Endoplasmic reticulum, Glycoprotein, Golgi apparatus, Hydrolase, Ion transport, Magnesium, Membrane, Metal-binding, Neurodegeneration, Nucleotide-binding, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Transmembrane, Transmembrane helix, Transport
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.310.000116RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.420.00155RNA microarray19698090
Exp24172336Mus musculus6kidneycortexAKI (AKI)0.560.041312596LC-MS/MS24172336

Compile date 08-10-2018© iMODE-CKD consortium