CKDdb-logoCKDdb - Molecule ID A5852

geneATP2C1, PMR1L, HUSSY-28
nameCalcium-transporting ATPase type 2C
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AT2C1_HUMANP98194ENSG0000001726027032Hs.584884169600, 604384

Functions and classifications

GOC:Golgi apparatus, C:Golgi membrane, C:integral component of membrane, C:trans-Golgi network, F:ATP binding, F:calcium ion binding, F:calcium-transporting ATPase activity, F:manganese ion binding, F:manganese-transporting ATPase activity, F:metal ion binding, F:signal transducer activity, P:actin cytoskeleton reorganization, P:calcium-dependent cell-cell adhesion, P:cellular calcium ion homeostasis, P:cellular manganese ion homeostasis, P:epidermis development, P:Golgi calcium ion homeostasis, P:Golgi calcium ion transport, P:positive regulation of I-kappaB kinase/NF-kappaB signaling, P:ATP catabolic process, P:calcium ion transmembrane transport, F:cation-transporting ATPase activity, P:ion transmembrane transport, C:integral to membrane, P:ATP biosynthetic process, P:positive regulation of I-kappaB kinase/NF-kappaB cascade, C:integral to membrane, F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, P:cation transport
UniProtAlternative splicing, ATP-binding, Calcium, Calcium transport, Complete proteome, Disease mutation, Golgi apparatus, Hydrolase, Ion transport, Magnesium, Membrane, Metal-binding, Nucleotide-binding, Polymorphism, Reference proteome, Transmembrane, Transmembrane helix, Transport, Phosphoprotein
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.170.0105RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.670.0122RNA microarray19698090
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.34< 0.05RNA microarray21752957
Exp24172336Mus musculus6kidneycortexAKI (AKI)2.040.049812581LC-MS/MS24172336
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.332.73E-05RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.472.96E-03RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.493.34E-03RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium