CKDdb-logoCKDdb - Molecule ID A5842

geneAss
nameArgininosuccinate synthase
speciesRattus norvegicus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ASSY_RATP09034ENSRNOG0000000883725698Rn.5078215700, 603470

Functions and classifications

GOC:cell body fiber, C:cytoplasm, C:endoplasmic reticulum, C:lysosome, C:mitochondrial outer membrane, C:neuron projection, C:neuronal cell body, C:nucleus, C:perikaryon, F:argininosuccinate synthase activity, F:ATP binding, F:toxic substance binding, P:acute-phase response, P:aging, P:arginine biosynthetic process, P:argininosuccinate metabolic process, P:cellular response to amine stimulus, P:cellular response to amino acid stimulus, P:cellular response to ammonium ion, P:cellular response to cAMP, P:cellular response to dexamethasone stimulus, P:cellular response to glucagon stimulus, P:cellular response to interferon-gamma, P:cellular response to lipopolysaccharide, P:cellular response to oleic acid, P:cellular response to tumor necrosis factor, P:diaphragm development, P:kidney development, P:liver development, P:midgut development, P:response to acid, P:response to amine, P:response to amino acid, P:response to drug, P:response to estradiol, P:response to fatty acid, P:response to glucocorticoid, P:response to growth hormone, P:response to lipopolysaccharide, P:response to mycotoxin, P:response to nutrient, P:response to peptide hormone, P:response to steroid hormone, P:response to zinc ion, P:urea cycle, F:toxin binding, P:response to estradiol stimulus, P:response to growth hormone stimulus
UniProtAmino-acid biosynthesis, Arginine biosynthesis, ATP-binding, Complete proteome, Ligase, Nucleotide-binding, Phosphoprotein, Reference proteome, Urea cycle
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.230.03cDNA microarray19099603
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.320.01cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.380cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.390cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.40cDNA microarray19099603
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.431.72E-05RNA microarray20019191
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.130.0000313RNA microarray23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.140.00147RNA microarray23291264
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)0.71 nLC-ESI-UHR-QToF-MS/MS23344851
Exp24090408Rattus norvegicus28kidneycortexChronic_Renal_Insufficiency (early_stage_CKD)down 2DE, LC-MS/MS24090408
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model)0.71< 0.05LC-MS/MS24497609
Exp25279147Homo sapiens12kidneybiopsy sectionGlomerulonephritis (IgA nephropathy)0.36< 0.05MALDI TOF/TOF25279147
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)85.110.003182RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium