CKDdb-logoCKDdb - Molecule ID A5831

geneASAH1, ASAH, HSD33
nameAcid ceramidase precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ASAH1_HUMANQ13510ENSG00000104763427Hs.527412159950, 228000, 613468

Functions and classifications

GOC:lysosomal lumen, F:ceramidase activity, P:cell death, P:ceramide metabolic process, P:glycosphingolipid metabolic process, P:lung development, P:response to organic substance, P:small molecule metabolic process, F:hydrolase activity, P:metabolic process, C:lysosome, P:lipid metabolic process, P:phospholipid metabolic process
UniProtAlternative splicing, Complete proteome, Direct protein sequencing, Disease mutation, Epilepsy, Glycoprotein, Hydrolase, Lysosome, Neurodegeneration, Polymorphism, Reference proteome, Signal
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)3.741.43E-08RNA microarray19698090
Exp20940332Mus musculus kidneycollecting duct cellsVasopressine_induced (Vasopressine in vitro model)1.32< 0.05LC-MS/MS20940332
Exp24096133bHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy)1000 1DE, MALDI24096133
Exp24096133cHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy)1000 1DE, MALDI24096133
Exp24096133dHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy vs type 1 diabetes without retinopathy or nephropathy)1000 1DE, MALDI24096133
Exp24096133eHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes without retinopathy or nephropathy)1000 1DE, MALDI24096133
Exp24096133fHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes with retinopathy)0.21 1DE, MALDI24096133
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model)1.41< 0.05LC-MS/MS24497609
Exp25578432aHomo sapiens60urinesupernatantDiabetes (type 2 diabetes without nephropathy)1.280.07LC-MS/MS25578432
Exp25578432bHomo sapiens42urinesupernatantDiabetes (type 2 diabetes with retinopathy)1.786E10-5LC-MS/MS25578432
Exp25578432cHomo sapiens51urinesupernatantDiabetes (diabetes with overt diabetic nephropathy)0.961LC-MS/MS25578432

Compile date 08-10-2018© iMODE-CKD consortium