CKDdb-logoCKDdb - Molecule ID A5827

geneAsl
nameArgininosuccinate lyase
speciesRattus norvegicus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARLY_RATP20673ENSRNOG0000000090359085Rn.64591207900, 608310

Functions and classifications

GOC:cell body fiber, C:cytoplasm, C:endoplasmic reticulum, C:mitochondrial outer membrane, C:neuronal cell body, C:nucleus, C:perikaryon, C:perinuclear region of cytoplasm, F:argininosuccinate lyase activity, P:aging, P:arginine biosynthetic process, P:arginine biosynthetic process via ornithine, P:argininosuccinate metabolic process, P:cellular response to ammonium ion, P:cellular response to cAMP, P:cellular response to dexamethasone stimulus, P:cellular response to glucagon stimulus, P:cellular response to glucocorticoid stimulus, P:cellular response to hypoxia, P:cellular response to interferon-gamma, P:cellular response to tumor necrosis factor, P:diaphragm development, P:internal protein amino acid acetylation, P:kidney development, P:liver development, P:midgut development, P:response to acid, P:response to amine, P:response to drug, P:response to growth hormone, P:response to lipopolysaccharide, P:response to nutrient, P:response to peptide hormone, P:response to steroid hormone, P:response to zinc ion, P:urea cycle, P:ammonia assimilation cycle, P:locomotory behavior, P:post-embryonic development, P:response to amine stimulus, P:response to growth hormone stimulus, F:argininosuccinate lyase activity, P:ammonia assimilation cycle, P:arginine biosynthetic process via ornithine, P:locomotory behavior, P:post-embryonic development, , C:cytoplasm, F:argininosuccinate lyase activity, P:ammonia assimilation cycle, P:arginine biosynthetic process via ornithine, P:locomotory behavior, P:post-embryonic development
UniProtAcetylation, Amino-acid biosynthesis, Arginine biosynthesis, Complete proteome, Lyase, Polymorphism, Reference proteome, Urea cycle, , ,
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.350.00246RNA microarray23291264
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model)0.71< 0.05LC-MS/MS24497609
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)5.720.010439RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium