CKDdb-logoCKDdb - Molecule ID A5825

geneAKR7A3, AFAR2
nameAflatoxin B1 aldehyde reductase 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARK73_HUMANO95154ENSG0000016248222977Hs.6980608477

Functions and classifications

GOC:cytosol, F:alditol:NADP+ 1-oxidoreductase activity, F:aldo-keto reductase (NADP) activity, F:electron carrier activity, P:aflatoxin catabolic process, P:cellular aldehyde metabolic process
UniProt3D-structure, Complete proteome, Cytoplasm, NAD, NADP, Oxidoreductase, Polymorphism, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.350.00000821RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.470.0278RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.421.50E-05RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.453.00E-05RNA microarray20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)2.560.043MALDI-TOF/TOF21544065
Exp22061828Rattus norvegicus kidney Gentamicin_induced (Gentamicin-induced nephropathy)0.365.80E-03Nano RP-LC, MALDI-TOF22061828
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)0.35 nLC-ESI-UHR-QToF-MS/MS23344851
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.35< 0.05RNA-seq23757392
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)9.570.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium