CKDdb-logoCKDdb - Molecule ID A5822

geneARG2
nameArginase-2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARGI2_HUMANP78540ENSG00000081181384Hs.226007107830

Functions and classifications

GOC:mitochondrial matrix, F:arginase activity, F:metal ion binding, P:arginine metabolic process, P:nitric oxide biosynthetic process, P:striated muscle contraction, P:urea cycle, P:ureteric bud development, P:apoptotic process, P:cellular response to dexamethasone stimulus, P:cellular response to interferon-gamma, P:cellular response to lipopolysaccharide, P:lung development, P:maternal process involved in female pregnancy, P:midgut development, P:negative regulation of nitric-oxide synthase activity, P:negative regulation of striated muscle contraction, P:regulation of L-arginine import, P:regulation of nitric oxide biosynthetic process, P:response to amine stimulus, P:response to amino acid stimulus, P:response to axon injury, P:response to cadmium ion, P:response to drug, P:response to glucose stimulus, P:response to herbicide, P:response to hypoxia, P:response to mercury ion, P:response to selenium ion, P:response to vitamin E
UniProt3D-structure, Arginine metabolism, Complete proteome, Hydrolase, Manganese, Metal-binding, Mitochondrion, Polymorphism, Reference proteome, Transit peptide, Urea cycle
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)5.810.05RNA microarray17579666
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.440.000138RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.357.27E-05RNA microarray20019191
Exp21411733aMus musculus13macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)2.340.001cDNA microarray21411733
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.31< 0.05RNA microarray21752957
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.370.006797096LC-MS/MS24172336

Compile date 08-10-2018© iMODE-CKD consortium