CKDdb-logoCKDdb - Molecule ID A5821

geneARG1
nameArginase 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARGI1_HUMANP05089ENSG00000118520383Hs.440934207800, 608313

Functions and classifications

GOC:cytosol, C:extracellular space, C:neuron projection, C:neuronal cell body, F:arginase activity, F:manganese ion binding, P:arginine catabolic process, P:cellular response to dexamethasone stimulus, P:cellular response to glucagon stimulus, P:cellular response to hydrogen peroxide, P:cellular response to interleukin-4, P:cellular response to lipopolysaccharide, P:cellular response to transforming growth factor beta stimulus, P:collagen biosynthetic process, P:liver development, P:lung development, P:mammary gland involution, P:maternal process involved in female pregnancy, P:positive regulation of endothelial cell proliferation, P:protein homotrimerization, P:regulation of L-arginine import, P:response to amine, P:response to amino acid, P:response to axon injury, P:response to cadmium ion, P:response to drug, P:response to herbicide, P:response to manganese ion, P:response to methylmercury, P:response to selenium ion, P:response to vitamin A, P:response to vitamin E, P:response to zinc ion, P:urea cycle, P:response to amine stimulus, P:response to amino acid stimulus
UniProt3D-structure, Alternative splicing, Arginine metabolism, Complete proteome, Cytoplasm, Disease mutation, Hydrolase, Manganese, Metal-binding, Phosphoprotein, Polymorphism, Reference proteome, Urea cycle
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17579666bMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)5.90.05RNA microarray17579666
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)12.930.05RNA microarray17579666
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)4.140.04cDNA microarray19099603
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)2.230.0004877RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.320.00483RNA microarray19698090
Exp22114694Mus musculus6kidneyureterureteral_obstruction (unilateral hydronephrosis)39.8< 0.05RNA microarray22114694
Exp24316357Rattus norvegicus kidneyproximal tubule cellsureteral_obstruction (kidney obstruction in vitro model)0.570.008757372LC-MS/MS24316357
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.322.44E-03RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.160.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium