CKDdb-logoCKDdb - Molecule ID A5820

geneADRBK2, BARK2, GRK3
nameBeta-adrenergic receptor kinase 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARBK2_HUMANP35626ENSG00000100077157Hs.657494109636

Functions and classifications

GOF:ATP binding, F:beta-adrenergic receptor kinase activity, F:G-protein coupled receptor kinase activity, F:protein kinase activity, P:receptor internalization, P:signal transduction, P:termination of G-protein coupled receptor signaling pathway, F:phospholipid binding
UniProtATP-binding, Complete proteome, Kinase, Nucleotide-binding, Polymorphism, Reference proteome, Serine/threonine-protein kinase, Transferase, Ubl conjugation, Receptor
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)9.5< 0.05RNA microarray18187931
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.260.00599RNA microarray19698090
Exp25770168Homo sapiens17bloodmononuclear cellsGlomerulonephritis (IgA nephropathy)5.280.002RNA microarray25770168
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.170.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium