CKDdb-logoCKDdb - Molecule ID A5817

geneAPRT
nameAdenine phosphoribosyltransferase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APT_HUMANP07741ENSG00000198931353Hs.28914102600, 614723

Functions and classifications

GOC:cytosol, C:nucleus, F:adenine binding, F:adenine phosphoribosyltransferase activity, F:AMP binding, P:adenine salvage, P:AMP salvage, P:cellular response to insulin stimulus, P:grooming behavior, P:lactation, P:purine nucleobase metabolic process, P:purine ribonucleoside salvage, P:purine-containing compound salvage, F:transferase activity, transferring glycosyl groups, P:metabolic process, F:transferase activity, transferring glycosyl groups, F:transferase activity, P:nucleoside metabolic process
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Cytoplasm, Direct protein sequencing, Disease mutation, Glycosyltransferase, Phosphoprotein, Polymorphism, Purine salvage, Reference proteome, Transferase
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp16549904Mus musculus10urinewholeGlomerulonephritis (membranoproliferative glomerulonephritis model)0.89 nano-LC-MS/MS16549904
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.090.00118RNA microarray19698090
Exp20940332Mus musculus kidneycollecting duct cellsVasopressine_induced (Vasopressine in vitro model)0.66< 0.05LC-MS/MS20940332
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3< 0.05RNA microarray21752957
Exp22061828Rattus norvegicus kidney Gentamicin_induced (Gentamicin-induced nephropathy)2.624.10E-03Nano RP-LC, MALDI-TOF22061828

Compile date 08-10-2018© iMODE-CKD consortium