CKDdb-logoCKDdb - Molecule ID A5815

geneApex1, Ape, Apex
nameDNA-(apurinic or apyrimidinic site) lyase
speciesMus musculus

Molecule reference


Functions and classifications

GOC:centrosome, C:cytoplasm, C:endoplasmic reticulum, C:mitochondrion, C:nuclear speck, C:nucleolus, C:nucleoplasm, C:nucleus, C:perinuclear region of cytoplasm, C:transcription factor complex, F:3'-5' exonuclease activity, F:chromatin DNA binding, F:damaged DNA binding, F:DNA binding, F:DNA-(apurinic or apyrimidinic site) lyase activity, F:endoribonuclease activity, F:metal ion binding, F:oxidoreductase activity, F:phosphoric diester hydrolase activity, F:RNA binding, F:site-specific endodeoxyribonuclease activity, specific for altered base, F:transcription coactivator activity, P:aging, P:cell redox homeostasis, P:cellular response to cAMP, P:cellular response to hydrogen peroxide, P:cellular response to peptide hormone stimulus, P:DNA catabolic process, endonucleolytic, P:DNA demethylation, P:DNA recombination, P:DNA repair, P:negative regulation of smooth muscle cell migration, P:nucleic acid phosphodiester bond hydrolysis, P:positive regulation of DNA repair, P:positive regulation of G1/S transition of mitotic cell cycle, P:regulation of mRNA stability, P:regulation of transcription, DNA-templated, P:response to drug, P:transcription, DNA-templated, P:regulation of transcription, DNA-dependent, P:transcription, DNA-dependent, F:endonuclease activity
UniProtAcetylation, Activator, Cleavage on pair of basic residues, Complete proteome, Cytoplasm, Direct protein sequencing, Disulfide bond, DNA damage, DNA recombination, DNA repair, DNA-binding, Endonuclease, Endoplasmic reticulum, Exonuclease, Hydrolase, Lyase, Magnesium, Metal-binding, Mitochondrion, Nuclease, Nucleus, Phosphoprotein, Reference proteome, Repressor, RNA-binding, S-nitrosylation, Transcription, Transcription regulation, Ubl conjugation
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy)2.06< 0.05LC-MS/MS19845401

Compile date 08-10-2018© iMODE-CKD consortium