CKDdb-logoCKDdb - Molecule ID A5807

geneANG, RNASE5, HEL168
nameAngiogenin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ANGI_HUMANP03950ENSG00000214274283Hs.283749105850, 611895

Functions and classifications

GOC:angiogenin-PRI complex, C:basal lamina, C:extracellular space, C:growth cone, C:neuronal cell body, C:nucleolus, F:actin binding, F:copper ion binding, F:DNA binding, F:endonuclease activity, F:endoribonuclease activity, producing 3'-phosphomonoesters, F:heparin binding, F:peptide binding, F:receptor binding, F:ribonuclease activity, F:rRNA binding, P:actin filament polymerization, P:activation of phospholipase A2 activity, P:activation of phospholipase C activity, P:activation of protein kinase B activity, P:angiogenesis, P:cell communication, P:cell death, P:cell migration, P:diacylglycerol biosynthetic process, P:homeostatic process, P:negative regulation of smooth muscle cell proliferation, P:negative regulation of translation, P:oocyte maturation, P:ovarian follicle development, P:placenta development, P:positive regulation of endothelial cell proliferation, P:positive regulation of protein secretion, P:response to hormone, P:response to hypoxia, P:RNA phosphodiester bond hydrolysis, endonucleolytic, P:rRNA transcription, C:angiogenin-PRI complex, F:pancreatic ribonuclease activity, P:response to hormone stimulus, P:rRNA transcription
UniProt3D-structure, Amyotrophic lateral sclerosis, Angiogenesis, Basement membrane, Complete proteome, Developmental protein, Differentiation, Direct protein sequencing, Disease mutation, Disulfide bond, DNA-binding, Endonuclease, Extracellular matrix, Hydrolase, Neurodegeneration, Nuclease, Nucleus, Polymorphism, Protein synthesis inhibitor, Pyrrolidone carboxylic acid, Reference proteome, Secreted, Signal, Stress response
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)3.990.0000294RNA microarray19698090
Exp24189015aHomo sapiens5bloodmononuclear cellshealthy (healthy)2.15 +/- 0.99< 0.001RNA microarray24189015
Exp24189015bHomo sapiens9bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)2.67 +/- 0.66< 0.001RNA microarray24189015
Exp24189015cHomo sapiens10bloodmononuclear cellsDialysis (Peritoneal dialysis)3.16 +/- 0.45< 0.001RNA microarray24189015
Exp24189015dHomo sapiens17bloodmononuclear cellsDialysis (hemodialysis)3.45 +/- 0.51< 0.001RNA microarray24189015

Compile date 08-10-2018© iMODE-CKD consortium