CKDdb-logoCKDdb - Molecule ID A5788

geneAMACR
nameAlpha-methylacyl-CoA racemase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AMACR_HUMANQ9UHK6ENSG0000024211023600Hs.508343214950, 604489, 614307

Functions and classifications

GOC:mitochondrion, C:peroxisomal matrix, C:peroxisome, F:alpha-methylacyl-CoA racemase activity, P:bile acid biosynthetic process, P:fatty acid beta-oxidation using acyl-CoA oxidase, F:catalytic activity
UniProtAcetylation, Alternative splicing, Complete proteome, Disease mutation, Intrahepatic cholestasis, Isomerase, Mitochondrion, Peroxisome, Polymorphism, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.36< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.28< 0.05cDNA microarray17003339
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.450cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.380.01cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.260.000304RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.419.59E-06RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.472.26E-05RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.521.50E-05RNA microarray20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.20.000154RNA microarray23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.240.000481RNA microarray23291264
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.5< 0.05RNA-seq23757392
Exp24172336Mus musculus6kidneycortexAKI (AKI)2.270.022108183LC-MS/MS24172336
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.430.000954RNA microarray24569379
Exp24726496Rattus norvegicus kidneyglomeruliDiabetes (diabetic nephropathy)  LC-MS/MS24726496
Exp24927646aMus musculus16kidney Diabetes (diabetic nephropathy treated with Phlorizin)0.55< 0.05LC-MS/MS24927646
Exp24927646bMus musculus16kidney Diabetes (diabetic nephropathy)0.37< 0.05LC-MS/MS24927646

Compile date 08-10-2018© iMODE-CKD consortium