CKDdb-logoCKDdb - Molecule ID A5778

geneAlk
nameALK tyrosine kinase receptor
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ALK_MOUSEP97793ENSMUSG0000005547111682Mm.311854105590, 613014

Functions and classifications

GOC:integral component of plasma membrane, F:ATP binding, F:NF-kappaB-inducing kinase activity, F:transmembrane receptor protein tyrosine kinase activity, P:activation of MAPK activity, P:cell proliferation, P:neuron development, P:positive regulation of NF-kappaB transcription factor activity, P:protein autophosphorylation, P:regulation of apoptotic process, P:transmembrane receptor protein tyrosine kinase signaling pathway, P:nervous system development, C:integral component of membrane, P:peptidyl-tyrosine phosphorylation, F:kinase activity, C:integral to plasma membrane, C:integral to membrane
UniProt3D-structure, ATP-binding, Cell membrane, Chromosomal rearrangement, Complete proteome, Disease mutation, Glycoprotein, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Proto-oncogene, Receptor, Reference proteome, Repeat, Signal, Transferase, Transmembrane, Transmembrane helix, Tyrosine-protein kinase
PADBreceptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.240.032315097LC-MS/MS24172336
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.294.67E-03RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.327.31E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium