CKDdb-logoCKDdb - Molecule ID A5773

geneAKR1B1, ALDR1
nameAldose reductase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ALDR_HUMANP15121ENSG00000085662231Hs.521212103880

Functions and classifications

GOC:cytosol, C:extracellular space, C:nucleus, F:alditol:NADP+ 1-oxidoreductase activity, F:electron carrier activity, F:glyceraldehyde oxidoreductase activity, P:C21-steroid hormone biosynthetic process, P:carbohydrate metabolic process, P:daunorubicin metabolic process, P:doxorubicin metabolic process, P:response to stress, P:oxidation-reduction process, F:oxidoreductase activity, C:cytoplasm, P:small molecule metabolic process
UniProt3D-structure, Acetylation, Complete proteome, Cytoplasm, Direct protein sequencing, NADP, Oxidoreductase, Polymorphism, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.250cDNA microarray 19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.350cDNA microarray 19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.380cDNA microarray 19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.390cDNA microarray 19099603
Exp19688724Mus musculus kidneypodocytesHigh_glucose_induced (High glucose in vitro model)0.5< 0.05MALDI-TOF-MS 19688724
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)2.953.23E-06RNA microarray 20019191
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.472.47E-26NGS, RNA-seq. 22266139
Exp23760282aMus musculus kidneywholeureteral_obstruction (renal tubulointerstitial injury)0.270.011RNA microarray 23760282
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.290.019889449LC-MS/MS 24172336
Exp24316357Rattus norvegicus kidneyproximal tubule cellsureteral_obstruction (kidney obstruction in vitro model)1.470.008124571LC-MS/MSwestern blot 24316357

Compile date 08-10-2018© iMODE-CKD consortium