CKDdb-logoCKDdb - Molecule ID A5768

geneALDH8A1, ALDH12
nameAldehyde dehydrogenase 12
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AL8A1_HUMANQ9H2A2ENSG0000011851464577Hs.486520606467

Functions and classifications

GOC:cytoplasm, C:intracellular, F:retinal dehydrogenase activity, P:9-cis-retinoic acid biosynthetic process, P:retinal metabolic process, P:retinoic acid metabolic process, F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
UniProtAlternative splicing, Complete proteome, Cytoplasm, NAD, Oxidoreductase, Polymorphism, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.270.01cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.290cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.280.000247RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.32.62E-05RNA microarray20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.340.0021RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium