CKDdb-logoCKDdb - Molecule ID A5766

geneALDH4A1, ALDH4, P5CDH
nameDelta-1-pyrroline-5-carboxylate dehydrogenase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AL4A1_HUMANP30038ENSG000001594238659Hs.77448239510, 606811

Functions and classifications

GOC:mitochondrial matrix, F:1-pyrroline-5-carboxylate dehydrogenase activity, F:aldehyde dehydrogenase (NAD) activity, F:electron carrier activity, P:4-hydroxyproline catabolic process, P:cellular nitrogen compound metabolic process, P:proline biosynthetic process, P:proline catabolic process, P:proline catabolic process to glutamate, F:oxidoreductase activity, F:1-pyrroline-5-carboxylate dehydrogenase activity, F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Direct protein sequencing, Disease mutation, Mitochondrion, NAD, Oxidoreductase, Polymorphism, Proline metabolism, Reference proteome, Transit peptide
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.360.02cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.450cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.190.000000633RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.370.0000368RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.288.24E-06RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.363.23E-06RNA microarray20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp21544065cRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)0.350.006MALDI-TOF/TOF21544065
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)1.5 nLC-ESI-UHR-QToF-MS/MS23344851
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)5.290.009176RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)9.240.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium