CKDdb-logoCKDdb - Molecule ID A5761

geneAKT3, PKBG
nameRAC-gamma serine/threonine protein kinase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AKT3_HUMANQ9Y243ENSG0000011702010000Hs.498292603387, 611223

Functions and classifications

GOC:Golgi apparatus, C:nucleus, C:plasma membrane, F:ATP binding, F:protein serine/threonine kinase activity, P:mitochondrial genome maintenance, P:signal transduction, F:phospholipid binding
UniProt3D-structure, Acetylation, Alternative splicing, ATP-binding, Complete proteome, Cytoplasm, Disease mutation, Disulfide bond, Glycoprotein, Kinase, Membrane, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Serine/threonine-protein kinase, Transferase, Ubl conjugation
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)16.6< 0.05RNA microarray18187931
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.410.00837RNA microarray19698090
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.460cDNA microarray21411733
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.13< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.22< 0.05RNA microarray21752957
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.30.000000437RNA microarray24569379
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.160.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium