CKDdb-logoCKDdb - Molecule ID A5758

geneAKR1D1, SRD5B1
name3-oxo-5-beta-steroid 4-dehydrogenase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AK1D1_HUMANP51857ENSG000001227876718Hs.201667235555, 604741

Functions and classifications

GOC:cytosol, F:delta4-3-oxosteroid 5beta-reductase activity, F:steroid binding, P:androgen metabolic process, P:bile acid biosynthetic process, P:bile acid catabolic process, P:C21-steroid hormone metabolic process, P:cholesterol catabolic process, P:digestion, P:oxidation-reduction process, F:oxidoreductase activity, F:3-oxo-5-beta-steroid 4-dehydrogenase activity
UniProt3D-structure, Alternative splicing, Bile acid catabolism, Complete proteome, Cytoplasm, Disease mutation, Intrahepatic cholestasis, Lipid degradation, Lipid metabolism, NADP, Oxidoreductase, Reference proteome, Steroid metabolism
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.50.01cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.280.0232RNA microarray19698090
Exp23760282aMus musculus kidneywholeureteral_obstruction (renal tubulointerstitial injury)2.870.002RNA microarray23760282
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.321.02E-03RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.328.26E-04RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.170.013999RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.170.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium