CKDdb-logoCKDdb - Molecule ID A5756

geneAKR1C4, CHDR
nameAldo-keto reductase family 1 member C4
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AK1C4_HUMANP17516ENSG000001986101109Hs.567245600451, 614279

Functions and classifications

GOC:cytosol, F:aldo-keto reductase (NADP) activity, F:androsterone dehydrogenase activity, F:bile acid transmembrane transporter activity, F:chlordecone reductase activity, F:electron carrier activity, F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, F:retinal dehydrogenase activity, P:androgen metabolic process, P:bile acid biosynthetic process, P:cellular response to jasmonic acid stimulus, P:daunorubicin metabolic process, P:doxorubicin metabolic process, P:phototransduction, visible light, P:retinoid metabolic process, F:androsterone dehydrogenase (B-specific) activity, F:oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor, P:doxorubicin metabolic process"
UniProt3D-structure, Complete proteome, Cytoplasm, Direct protein sequencing, NADP, Oxidoreductase, Polymorphism, Reference proteome
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.293.14E-03RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium