CKDdb-logoCKDdb - Molecule ID A5755

geneAKR1C3, DDH1, HSD17B5
nameAldo-keto reductase family 1 member C3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AK1C3_HUMANP42330ENSG000001961398644Hs.78183603966

Functions and classifications

GOC:cytosol, C:nucleus, F:15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity, F:alditol:NADP+ 1-oxidoreductase activity, F:androsterone dehydrogenase activity, F:delta4-3-oxosteroid 5beta-reductase activity, F:dihydrotestosterone 17-beta-dehydrogenase activity, F:geranylgeranyl reductase activity, F:indanol dehydrogenase activity, F:ketoreductase activity, F:ketosteroid monooxygenase activity, F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, F:phenanthrene 9,10-monooxygenase activity, F:prostaglandin D2 11-ketoreductase activity, F:prostaglandin F receptor activity, F:prostaglandin-F synthase activity, F:retinal dehydrogenase activity, F:retinol dehydrogenase activity, F:testosterone 17-beta-dehydrogenase (NADP+) activity, F:testosterone dehydrogenase (NAD+) activity, F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity, P:cellular response to cadmium ion, P:cellular response to calcium ion, P:cellular response to corticosteroid stimulus, P:cellular response to jasmonic acid stimulus, P:cellular response to prostaglandin stimulus, P:cellular response to reactive oxygen species, P:cellular response to starvation, P:cyclooxygenase pathway, P:daunorubicin metabolic process, P:doxorubicin metabolic process, P:farnesol catabolic process, P:keratinocyte differentiation, P:male gonad development, P:multicellular organismal macromolecule metabolic process, P:negative regulation of retinoic acid biosynthetic process, P:phototransduction, visible light, P:positive regulation of cell proliferation, P:positive regulation of endothelial cell apoptotic process, P:positive regulation of protein kinase B signaling, P:positive regulation of reactive oxygen species metabolic process, P:progesterone metabolic process, P:protein import into nucleus, translocation, P:regulation of retinoic acid receptor signaling pathway, P:regulation of testosterone biosynthetic process, P:renal absorption, P:response to nutrient, P:retinal metabolic process, P:testosterone biosynthetic process, F:oxidoreductase activity, C:cytoplasm, F:androsterone dehydrogenase (A-specific) activity, F:oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor, P:positive regulation of protein kinase B signaling cascade, P:prostaglandin metabolic process
UniProt3D-structure, Complete proteome, Cytoplasm, NAD, NADP, Oxidoreductase, Polymorphism, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp15042541Homo sapiens4kidneyglomeruliDiabetes (diabetic nephropathy)3.8< 0.01RNA microarray15042541
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)4.640.000323RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.464.60E-05RNA microarray20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp22061828Rattus norvegicus kidney Gentamicin_induced (Gentamicin-induced nephropathy)0.365.30E-03Nano RP-LC, MALDI-TOF22061828
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.23< 0.05RNA-seq23757392
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy)0.4< 0.05RNA-seq23757392

Compile date 08-10-2018© iMODE-CKD consortium