CKDdb-logoCKDdb - Molecule ID A5754

geneAKR1C2, DDH2
nameAldo-keto reductase family 1 member C2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AK1C2_HUMANP52895ENSG00000151632101930400Hs.460260600450, 614279

Functions and classifications

GOC:cytoplasm, F:alditol:NADP+ 1-oxidoreductase activity, F:bile acid binding, F:ketosteroid monooxygenase activity, F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, F:phenanthrene 9,10-monooxygenase activity, F:prostaglandin F receptor activity, F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity, P:cellular response to jasmonic acid stimulus, P:daunorubicin metabolic process, P:digestion, P:doxorubicin metabolic process, P:positive regulation of cell proliferation, P:positive regulation of protein kinase B signaling, P:progesterone metabolic process, P:prostaglandin metabolic process, P:response to prostaglandin, F:oxidoreductase activity, F:androsterone dehydrogenase (A-specific) activity, F:oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor, P:positive regulation of protein kinase B signaling cascade, P:response to prostaglandin stimulus
UniProt3D-structure, Alternative splicing, Complete proteome, Cytoplasm, Direct protein sequencing, Disease mutation, Lipid metabolism, NADP, Oxidoreductase, Polymorphism, Reference proteome, Steroid metabolism
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.320.0032RNA microarray19698090

Compile date 08-10-2018© iMODE-CKD consortium