CKDdb-logoCKDdb - Molecule ID A5753

geneAKR1C1, DDH, DDH1
nameAldo-keto reductase family 1 member C1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AK1C1_HUMANQ04828ENSG000001871341645Hs.460260600449

Functions and classifications

GOC:cytosol, F:17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity, F:alditol:NADP+ 1-oxidoreductase activity, F:androsterone dehydrogenase (B-specific) activity, F:bile acid binding, F:indanol dehydrogenase activity, F:ketosteroid monooxygenase activity, F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, F:phenanthrene 9,10-monooxygenase activity, F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity, P:bile acid and bile salt transport, P:bile acid metabolic process, P:cellular response to jasmonic acid stimulus, P:cholesterol homeostasis, P:daunorubicin metabolic process, P:doxorubicin metabolic process, P:intestinal cholesterol absorption, P:phototransduction, visible light, P:progesterone metabolic process, P:protein homooligomerization, P:response to organophosphorus, P:retinal metabolic process, P:xenobiotic metabolic process, F:oxidoreductase activity, F:oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
UniProt3D-structure, Complete proteome, Cytoplasm, Direct protein sequencing, NADP, Oxidoreductase, Polymorphism, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.410.0191RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.531.72E-05RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.551.98E-05RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.553.59E-05RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.575.80E-05RNA microarray20019191
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.42< 0.05RNA microarray21752957
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.38< 0.05RNA-seq23757392
Exp23757392cRattus norvegicus18kidneywholeDiabetes (diabetic nephropathy)0.49< 0.05RNA-seq23757392

Compile date 08-10-2018© iMODE-CKD consortium