CKDdb-logoCKDdb - Molecule ID A5750

geneAKR1A1, ALDR1, ALR
nameAlcohol dehydrogenase [NADP+]
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AK1A1_HUMANP14550ENSG0000011744810327Hs.474584103830

Functions and classifications

GOC:apical plasma membrane, C:cytosol, F:alditol:NADP+ 1-oxidoreductase activity, F:electron carrier activity, F:L-glucuronate reductase activity, P:aldehyde catabolic process, P:cellular aldehyde metabolic process, P:D-glucuronate catabolic process, P:glucose metabolic process, P:L-ascorbic acid biosynthetic process
UniProt3D-structure, Acetylation, Complete proteome, Direct protein sequencing, NADP, Oxidoreductase, Polymorphism, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17609286Mus musculus10kidneyglomeruliDiabetes (diabetic nephropathy in Type 1 diabetes)up< 0.05MALDI-TOF-MS17609286
Exp17881425Mus musculus12urinewholeGlomerulonephritis (focal segmental glomerulosclerosis)  MALDI-TOF-MS17881425
Exp19688726aRattus norvegicus kidneyinterstitial fibroblastFibrosis (TGFbeta in vitro model)2.83 MALDI-TOF19688726
Exp19688726aRattus norvegicus kidneyinterstitial fibroblastFibrosis (TGFbeta in vitro model)5.66 MALDI-TOF19688726
Exp19688726bRattus norvegicus kidneyinterstitial fibroblastFibrosis (TGFbeta in vitro model)8 MALDI-TOF19688726
Exp19688726bRattus norvegicus kidneyinterstitial fibroblastFibrosis (TGFbeta in vitro model)8 MALDI-TOF19688726
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.010.0000383RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.542.62E-05RNA microarray20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)0.72 nLC-ESI-UHR-QToF-MS/MS23344851
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)9.350.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium