CKDdb-logoCKDdb - Molecule ID A5733

geneADK
nameAdenosine kinase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADK_HUMANP55263ENSG00000156110132Hs.656586102750, 614300

Functions and classifications

GOC:cytosol, C:nucleus, F:adenosine kinase activity, F:ATP binding, F:metal ion binding, F:phosphotransferase activity, alcohol group as acceptor, P:adenosine metabolic process, P:AMP salvage, P:circadian regulation of gene expression, P:dATP biosynthetic process, P:positive regulation of cardiac muscle hypertrophy, P:positive regulation of T cell proliferation, P:purine nucleobase metabolic process, P:purine ribonucleoside salvage, P:purine-containing compound salvage, P:type B pancreatic cell proliferation, F:adenosine kinase activity, P:AMP biosynthetic process, P:purine ribonucleoside salvage, C:cytosol, P:type B pancreatic cell proliferation, P:purine-containing compound salvage
UniProt3D-structure, Acetylation, Alternative splicing, ATP-binding, Complete proteome, Cytoplasm, Direct protein sequencing, Disease mutation, Kinase, Magnesium, Metal-binding, Nucleotide-binding, Nucleus, Phosphoprotein, Purine salvage, Reference proteome, Transferase
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.430.01cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.430.01cDNA microarray19099603
Exp19688724Mus musculus kidneypodocytesHigh_glucose_induced (High glucose in vitro model)0< 0.05MALDI-TOF-MS19688724
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)4.510.0099003RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.890.0332RNA microarray19698090
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy)2.83< 0.05LC-MS/MS19845401
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.920.013755561LC-MS/MS24172336

Compile date 08-10-2018© iMODE-CKD consortium