CKDdb-logoCKDdb - Molecule ID A5717

geneADAM9, MCMP, MDC9
nameADAM 9 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADAM9_HUMANQ13443ENSG000001686158754Hs.591852602713, 612775

Functions and classifications

GOC:basolateral plasma membrane, C:cytoplasm, C:extracellular space, C:integral component of membrane, C:intrinsic component of external side of plasma membrane, F:collagen binding, F:integrin binding, F:laminin binding, F:metalloendopeptidase activity, F:protein kinase C binding, F:SH3 domain binding, F:zinc ion binding, P:activation of MAPKK activity, P:cell-cell adhesion mediated by integrin, P:cell-matrix adhesion, P:cellular response to lipopolysaccharide, P:collagen catabolic process, P:extracellular matrix disassembly, P:integrin-mediated signaling pathway, P:keratinocyte differentiation, P:monocyte activation, P:PMA-inducible membrane protein ectodomain proteolysis, P:positive regulation of cell adhesion mediated by integrin, P:positive regulation of keratinocyte migration, P:positive regulation of macrophage fusion, P:positive regulation of membrane protein ectodomain proteolysis, P:positive regulation of protein secretion, P:response to calcium ion, P:response to glucocorticoid, P:response to hydrogen peroxide, P:response to laminar fluid shear stress, P:response to manganese ion, P:response to tumor necrosis factor, P:transforming growth factor beta receptor signaling pathway, P:membrane protein ectodomain proteolysis, P:proteolysis, C:extracellular region, C:integral to membrane, C:intrinsic to external side of plasma membrane, F:metal ion binding, P:response to glucocorticoid stimulus
UniProt3D-structure, Alternative splicing, Cell membrane, Complete proteome, Cone-rod dystrophy, Disulfide bond, Glycoprotein, Hydrolase, Membrane, Metal-binding, Metalloprotease, Protease, Reference proteome, Secreted, Signal, Transmembrane, Transmembrane helix, Zinc, Integrin
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)2.830.011349RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)8.320.00000188RNA microarray19698090
Exp22343120Homo sapiens39kidney AKI (AKI)2.90.009RNA microarray22343120
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.440.006797096LC-MS/MS24172336
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.353.75E-05RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.492.95E-03RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)2.224.55E-03RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium