CKDdb-logoCKDdb - Molecule ID A5711

geneAdam17, Tace
nameDisintegrin and metalloproteinase domain-containing protein 17
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADA17_MOUSEQ9Z0F8ENSMUSG0000005259311491Mm.27681603639, 614328

Functions and classifications

GOC:actin cytoskeleton, C:apical plasma membrane, C:cell surface, C:cell-cell junction, C:cytoplasm, C:extracellular region, C:focal adhesion, C:integral component of plasma membrane, C:membrane raft, C:plasma membrane, C:ruffle membrane, F:metalloendopeptidase activity, F:metallopeptidase activity, F:Notch binding, F:protein binding, F:zinc ion binding, P:B cell differentiation, P:cell adhesion mediated by integrin, P:cell motility, P:epidermal growth factor receptor signaling pathway, P:epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway, P:germinal center formation, P:membrane protein ectodomain proteolysis, P:negative regulation of interleukin-8 production, P:Notch receptor processing, P:Notch signaling pathway, P:PMA-inducible membrane protein ectodomain proteolysis, P:positive regulation of cell growth, P:positive regulation of cell proliferation, P:positive regulation of cellular component movement, P:positive regulation of chemokine production, P:positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle, P:positive regulation of T cell chemotaxis, P:positive regulation of transforming growth factor beta receptor signaling pathway, P:proteolysis, P:regulation of mast cell apoptotic process, P:response to drug, P:response to high density lipoprotein particle, P:response to hypoxia, P:response to lipopolysaccharide, P:spleen development, P:T cell differentiation in thymus, P:wound healing, spreading of epidermal cells, C:cytoplasm, F:metalloendopeptidase activity, F:protein binding, F:zinc ion binding, C:cytoplasm, F:protein binding, P:integrin-mediated signaling pathway, C:cytoplasm, F:metalloendopeptidase activity, F:protein binding, F:zinc ion binding, C:cytoplasm, F:metalloendopeptidase activity, F:protein binding, F:zinc ion binding, C:cytoplasm, F:metalloendopeptidase activity, F:protein binding, F:zinc ion binding, C:cytoplasm, F:metalloendopeptidase activity, F:protein binding, F:zinc ion binding, C:cytoplasm, F:protein binding, C:cytoplasm, F:metalloendopeptidase activity, F:protein binding, F:zinc ion binding, P:integrin-mediated signaling pathway, C:actin cytoskeleton, C:apical plasma membrane, C:cell surface, C:cell-cell junction, C:cytoplasm, C:extracellular region, C:focal adhesion, C:integral component of plasma membrane, C:membrane raft, C:ruffle membrane, F:metalloendopeptidase activity, F:protein binding, F:zinc ion binding, P:cell adhesion mediated by integrin, P:epidermal growth factor receptor signaling pathway, P:epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway, P:negative regulation of interleukin-8 production, P:Notch receptor processing, P:PMA-inducible membrane protein ectodomain proteolysis, P:positive regulation of cell growth, P:positive regulation of cell proliferation, P:positive regulation of chemokine production, P:positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle, P:positive regulation of T cell chemotaxis, P:response to high density lipoprotein particle, P:response to hypoxia, P:response to lipopolysaccharide, P:wound healing, spreading of epidermal cells, C:cytoplasm, F:metalloendopeptidase activity, F:protein binding, F:zinc ion binding
UniProtAlternative splicing, Cell membrane, Cleavage on pair of basic residues, Complete proteome, Disulfide bond, Glycoprotein, Hydrolase, Membrane, Metal-binding, Metalloprotease, Notch signaling pathway, Phosphoprotein, Protease, Reference proteome, Secreted, SH3-binding, Signal, Transmembrane, Transmembrane helix, Zinc, Zymogen, Integrin
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)2.3< 0.05RNA microarray18187931
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)2.915.52E-06RNA microarray20019191
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.14< 0.05RNA microarray21752957
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)0.150.0028513RNA microarray23935909
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model)0.62< 0.05LC-MS/MS24497609
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.450.00018RNA microarray24569379
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.413.48E-05RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium