CKDdb-logoCKDdb - Molecule ID A5709

geneADAM12, MLTN, UNQ346/PRO545
nameADAM 12 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADA12_HUMANO43184ENSG000001488488038Hs.594351602714

Functions and classifications

GOC:extracellular region, C:integral component of membrane, C:mitochondrion, C:nucleus, C:plasma membrane, F:metalloendopeptidase activity, F:metallopeptidase activity, F:zinc ion binding, P:cell adhesion, P:epidermal growth factor receptor signaling pathway, P:myoblast fusion, P:proteolysis, C:integral to membrane, F:metal ion binding
UniProtAlternative splicing, Cell adhesion, Cell membrane, Cleavage on pair of basic residues, Complete proteome, Disulfide bond, EGF-like domain, Glycoprotein, Hydrolase, Membrane, Metal-binding, Metalloprotease, Phosphoprotein, Polymorphism, Protease, Reference proteome, Secreted, SH3-binding, Signal, Transmembrane, Transmembrane helix, Zinc, Zymogen
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)2.2< 0.05RNA microarray 18187931
Exp19398767Homo sapiens20kidneybiopsy sectionFibrosis (Interstitial fibrosis and tubular atrophy)2.250.000794624RNA microarrayRT-qPCR19398767
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.160.00000479RNA microarray 19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.20.00151RNA microarray 19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.280.00902RNA microarray 19698090
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)3.273.71E-35NGS, RNA-seq. 22266139
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)0.240.0074022RNA microarray 23935909
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.160.013999RNA microarray 26317775

Compile date 08-10-2018© iMODE-CKD consortium