CKDdb-logoCKDdb - Molecule ID A5708

geneAda
nameAdenosine deaminase
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADA_MOUSEP03958ENSMUSG0000001769711486Mm.388102700, 608958

Functions and classifications

GOC:cell junction, C:cytoplasm, C:cytoplasmic membrane-bounded vesicle lumen, C:cytosol, C:dendrite cytoplasm, C:external side of plasma membrane, C:extracellular space, C:lysosome, C:neuronal cell body, F:adenosine deaminase activity, F:purine nucleoside binding, F:zinc ion binding, P:adenosine catabolic process, P:aging, P:cell adhesion, P:dATP catabolic process, P:deoxyadenosine catabolic process, P:embryonic digestive tract development, P:germinal center B cell differentiation, P:histamine secretion, P:hypoxanthine biosynthetic process, P:hypoxanthine salvage, P:in utero embryonic development, P:inosine biosynthetic process, P:liver development, P:lung alveolus development, P:lung development, P:negative regulation of adenosine receptor signaling pathway, P:negative regulation of apoptotic process, P:negative regulation of circadian sleep/wake cycle, non-REM sleep, P:negative regulation of inflammatory response, P:negative regulation of leukocyte migration, P:negative regulation of mature B cell apoptotic process, P:negative regulation of mucus secretion, P:negative regulation of penile erection, P:negative regulation of thymocyte apoptotic process, P:Peyer's patch development, P:placenta development, P:positive regulation of alpha-beta T cell differentiation, P:positive regulation of B cell proliferation, P:positive regulation of calcium-mediated signaling, P:positive regulation of germinal center formation, P:positive regulation of heart rate, P:positive regulation of smooth muscle contraction, P:positive regulation of T cell activation, P:positive regulation of T cell differentiation, P:positive regulation of T cell differentiation in thymus, P:positive regulation of T cell receptor signaling pathway, P:purine nucleotide salvage, P:purine ribonucleoside monophosphate biosynthetic process, P:regulation of cell-cell adhesion mediated by integrin, P:regulation of T cell differentiation, P:response to drug, P:response to hydrogen peroxide, P:response to hypoxia, P:response to morphine, P:response to vitamin E, P:T cell activation, P:trophectodermal cell differentiation, P:xanthine biosynthetic process
UniProt3D-structure, Acetylation, Cell adhesion, Cell junction, Cell membrane, Complete proteome, Cytoplasm, Cytoplasmic vesicle, Hydrolase, Membrane, Metal-binding, Nucleotide metabolism, Reference proteome, Zinc
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)4.02< 0.05RNA microarray21752957
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.440.000116RNA microarray24569379
Exp24798088Rattus norvegicus kidney AKI (AKI)0.230.019MS/MS24798088

Compile date 08-10-2018© iMODE-CKD consortium